ED Mathématiques et Informatique
Intermediate hyperbolicity of varieties supporting a variation of Hodge structure and applications in positive characteristic
by Éloan RAPION (IMB - Institut de Mathématiques de Bordeaux)
The defense will take place at 14h00 - Salle de conférences Institut de Mathématiques de Bordeaux 351 cours de la Libération - 33405 Talence
in front of the jury composed of
- Yohan BRUNEBARBE - Chargé de recherche - Institut de Mathématiques de Bordeaux - Directeur de these
- Benoît CADOREL - Maître de conférences - Institut Élie Cartan de Lorraine - Rapporteur
- Ekaterina AMERIK - Professeure - Université de Paris-Sud - Examinateur
- Benjamin BAKKER - Associate Professor - University of Illinois - Examinateur
- Sébastien BOUCKSOM - Directeur de recherche - Institut de Mathématiques de Jussieu - Paris Rive Gauche - Examinateur
- Simone DIVERIO - Professeur - SAPIENZA Università di Roma - Examinateur
- Henri GUENANCIA - Directeur de recherche - Institut de Mathématiques de Bordeaux - Examinateur
Let V be a smooth complex quasiprojective manifold. Suppose it supports a variation of Hodge structure whose period map is generically immersive. Then V exhibits various hyperbolicity properties. In particular, let (W, D) be a smooth logarithmic compactification of V. Then, according to the work of Zuo, Brunebarbe, Klingler, Totaro, and Cadorel, the logarithmic cotangent and logarithmic canonical vector bundles are big. In this thesis, we study the positivity of the vector bundles $Omega_W^p(log D)$ for all p. We show that they are all big. We also show that for sufficiently large p, they are big in the (stronger) Viehweg sense. We develop the example of the moduli space of polarized quintic threefolds. We then turn our attention to the special case of locally symmetric varieties. We explicitly compute the augmented base loci associated with the $Omega_W^p(log D)$. These sets describe the "amplitude defect" of a vector bundle. We also compute the stable base locus associated with the logarithmic cotangent bundle (case p=1). This stable base locus describes the set of tangent vectors on which every logarithmic symmetric differential form of degree 1 vanishes. These two results generalize a calculation performed by Mok under the assumptions p=1 and V compact. We present two applications in positive characteristic. First, we prove an isotriviality theorem for families of curves parameterized by the moduli space of principally polarized Abelian varieties. The proof requires the study of absolutely logarithmic differential forms defined by Abramovich (to compensate for the lack of smooth logarithmic compactifications in positive characteristic). Second, we consider the "Arakelov theorem" for Abelian schemes proven by Faltings. This states that on a smooth complex algebraic variety, there are only a finite number of Abelian schemes satisfying a certain property. We demonstrate that a version of this theorem holds in positive characteristic. We also prove a similar statement for families of K3 surfaces.
ED Sciences Chimiques
Synthesis and Evaluation of Peptide Compounds for the Targeted Degradation of Oncoproteins
by Mathieu BOURGEAIS (Institut de Chimie & de Biologie des Membranes & des Nano-objets)
The defense will take place at 9h00 - Amphithéatre 2 Rue Robert Escarpit, IECB, 33600, Pessac
in front of the jury composed of
- Gilles GUICHARD - Directeur de recherche - Université de Bordeaux - Directeur de these
- Marie LOPEZ - Chargée de recherche - Université de Montpellier - Rapporteur
- Didier BOTURYN - Directeur de recherche - Université de Grenoble - Rapporteur
- Prisca BOISGUERIN - Directrice de recherche - Université de Montpellier - Examinateur
- Abdel-Majid KHATIB - Directeur de recherche - Université de Bordeaux - CoDirecteur de these
- Morgane PASCO - Chargée de recherche - Université de Bordeaux - Examinateur
This thesis focuses on the design, synthesis, and evaluation of innovative peptide and peptidomimetic compounds aimed at modulating and selectively degrading oncoproteins. Owing to their intrinsic selectivity and modularity, peptides represent privileged scaffolds for targeting protein-protein interfaces that are typically inaccessible to small molecules, as well as for harnessing endogenous cellular degradation pathways. In this context, two major targets were investigated: hDM2, due to its E3 ligase activity and its regulatory interaction with the tumor suppressor p53, and furin, a proprotein convertase implicated in tumor progression. In the first part, constrained ligands mimicking the native -helix of p53 were developed as peptide-foldamer hybrids incorporating oligourea segments and macrocyclization strategies guided by co-crystal structures with hDM2. The exploration of new cyclization opportunities that stabilize the native -helical motif, particularly through the introduction of cysteine residues and a mercaptoproline unit, enabled the rigidification of high-affinity hDM2/hDMX binders. Fine-tuning of the sequences further revealed that polycationic extensions induced p53-independent cytotoxicity, whereas neutral macrocyclic peptide-foldamer hybrids successfully restored p53 anti-tumor activity in p53wt cancer cells. These optimized ligands constitute high-affinity, stable, and cell-permeable modules suitable for integration into peptidomimetic PROTAC architectures exploiting hDM2 as a target or an E3 ligase. In the second part, a robust synthetic route to furin peptide inhibitors was established, yielding analogues active against recombinant enzyme and in cells. These ligands were subsequently used to explore targeted degradation strategies including hydrophobic tagging, PROTACs engaging the E3 ligases Cereblon or von Hippel–Lindau, and LYTACs designed to recruit internalizing surface receptors. The results highlight both the promise and the limitations of these approaches, the latter being largely driven by the membrane localization and luminal orientation of furin, which restrict the efficiency of certain degradation modalities. Overall, this work demonstrates that peptidomimetic engineering combined with macrocyclization provides a powerful platform for generating bifunctional tools capable of selectively degrading oncoproteins. These advances pave the way for next-generation degraders targeting both intra- and extracellular proteins, illustrating how such architectures can be rationally optimized for high affinity, enhanced stability, and efficient addressing through proteasomal or lysosomal degradation pathways.
ED Entreprise Economie Société
Functional Services and Corporate Social Responsibility: Supporting Operational Staff Toward a Sense-Based Appropriation of CSR. A Study at the Intersection of Strategy-as-Practice, Neo-Institutional Theory, and the Economics of Worth.
by Alain JONIK (IRGO - Institut de Recherche en Gestion des Organisations)
The defense will take place at 9h30 - C107 Pôle Universitaire des Sciences de Gestion - Bâtiment C. 35 avenue Abadie, 33000 BORDEAUX
in front of the jury composed of
- Julien CUSIN - Professeur des universités - UNIVERSITE DE BORDEAUX - Directeur de these
- Bertrand VALIORGUE - Professeur des universités - EM LYON BUSINESS SCHOOL - Rapporteur
- Sandra CHARREIRE PETIT - Professeure des universités - UNIVERSITE DE PARIS-SACLAY - Rapporteur
- Laïla BENRAÏSS-NOAILLES - Professeure des universités - UNIVERSITE DE BORDEAUX - Examinateur
- Sandrine BERGER-DOUCE - Professeure - ECOLE DES MINES DE SAINT ETIENNE - Examinateur
- Christophe ESTAY - Professeur - EXCELIA BUSINESS SCHOOL - Examinateur
The literature highlights the role of middle managers as key actors steering the operational integration of Corporate Social Responsibility (CSR) within organizations (Current, 2012; Valiorgue, 2016a). However, it remains largely silent on the support provided by functional departments as instruments of implementation. By examining the institutional logics enacted by functional services—still understudied in CSR operationalization processes—this research contributes to the micro-level CSR literature, which remains marginal (4% of publications, Aguinis & Glavas, 2012) and predominantly situated within the Strategy-as-Practice (SAP) theoretical field. Most of these studies focus on a vertical approach, following the hierarchical line from top management to operational levels (Valiorgue, 2016; Daudigeos, 2019). Yet, rendering CSR tangible requires a joint consideration of normative, regulatory, certified, and ideological frameworks (Mintzberg, 1982, 2003), as well as the ways in which actors think, interpret, and articulate who they are, how they perceive others, and the organizational issues they face (Hasselbladh & Kallinikos, 2000). Consequently, addressing the micro-level dimension of CSR implies situating it within an institutionally embedded vision, which invites complementing the SAP approach with the Neo-Institutional Theory (NIT). Studying CSR through the lens of a functional department also calls for a nuanced reading of the usual NIT dichotomy between “dominant” and “dominated” actors (Bourdieu, 1980). In this perspective, the Economics of Worth framework (Boltanski & Thévenot, 1991) provides a complementary theoretical contribution. This reflection leads to the following research question: Why and how do support services operationalize sensemaking processes that promote the appropriation of CSR by operational staff? To answer this question, an inductive qualitative design was applied through a single-case study conducted with Risk Prevention Engineers from the Suez Group. The study identifies sensemaking processes mobilized by functional services to make CSR tangible and actionable. In doing so, it enhances the convergence between SAP and NIT, extends the micro-foundational dimension of institutional theory, and enriches CSR research through the lens of the Economics of Worth. Ultimately, the study demonstrates that the analysis of horizontal linkages complements—and partly transcends—a purely vertical approach. It sheds light on functional services as instruments of “sense” construction (Balogun, 2003, Balogun et al., 2003) supporting operational actors. As transmission mechanisms, these services guide CSR-related actions by reconciling the interests of the firm, employees, and stakeholders.
responsibility, equity and insurance: essays in health and environmental economics
by Béka LOMIDZE (BSE - Bordeaux sciences économiques)
The defense will take place at 14h30 - Salle des Thèses (Salles DSPEG) 16 Av. Léon Duguit, 33600 Pessac
in front of the jury composed of
- Olivier BARGAIN - Professeur des universités - Université de Bordeaux - Directeur de these
- Jérôme WITTWER - Professeur des universités - Université de Bordeaux - CoDirecteur de these
- Michel GRIGNON - Professeur des universités - Université McMaster - Rapporteur
- Susana FERREIRA - Professeure des universités - Université de Géorgie, UGA - Rapporteur
- Léontine GOLDZAHL - Maîtresse de conférences - IÉSEG School of Management - Examinateur
This thesis examines individual preferences over inequality, redistribution, and risk management in health and climate contexts, combining survey experiments with quasi-experimental evidence. The first chapter exploits quasi-random exposure to storm Gudrun (Sweden, 2005) to identify medium-run effects on insurance demand and subjective well-being, documenting persistent increases in coverage alongside lasting welfare losses. The second chapter uses a nationally representative experimental survey in France (N=4,508) to study horizontal and vertical equity in healthcare financing, showing strong support for need-based compensation and weaker support when costs stem from individual choices. The third chapter shows that responsibility framing causally reduces health inequality aversion and amplifies gender gaps. Together, the results highlight how attribution, framing, and experience shape distributive preferences and the political sustainability of social insurance.
ED Sciences Physiques et de l'Ingénieur
Optimisation and implementation of digital communications beyond the Nyquist criterion
by Laëtitia JADOT (Laboratoire de l'Intégration du Matériau au Système)
The defense will take place at 10h00 - Amphi J.P.DOM A0.85, IMS Bordeaux IMS - Laboratoire de l'Intégration du Matériau au Système 351 Cours de la Libération, 33405 Talence Cedex, France
in front of the jury composed of
- Guillaume FERRE - Professeur des universités - Bordeaux INP - Directeur de these
- Karine AMIS - Professeure - IMT Atlantique - Rapporteur
- Charly POULLIAT - Professeur des universités - Toulouse INP - Rapporteur
- Nathalie DELTIMPLE - Professeure des universités - Bordeaux INP - Examinateur
- Damien ROQUE - Professeur - ISAE-SUPAERO - Examinateur
- Antonio CIPRIANO - Docteur - Thales - Examinateur
- Serdar SAHIN - Docteur - Thales - Examinateur
- Pascal CHEVALIER - Professeur du CNAM - CNAM - Examinateur
Modern digital transmissions must reconcile high data rates, low latency, and spectral efficiency requirements, while facing strict spectrum and energy constraints. In this context, Faster-Than-Nyquist (FTN) transmissions represent a promising approach to increase spectral efficiency, at the cost of inter-symbol interference (ISI) that must be handled at the receiver. While optimal receivers can manage this ISI, their computational complexity remains prohibitive for practical implementations. Turbo-iterative architectures based on approximate Bayesian inference, and in particular Expectation Propagation (EP), offer an attractive trade-off between performance and complexity, enabling the design of receivers capable of operating under aggressive FTN compression. In this thesis, we develop and analyze turbo-equalizers based on EP and Kalman smoothing, focusing on reducing complexity while maintaining performance comparable to that of a reference time-domain EP-based receiver. The scheduling of messages on factor graphs is studied to improve equalization performance in scenarios inspired by FTN satellite communications or high-speed vehicle mobile communications. With these receivers, we achieve improved equalization performance compared to linear EP-based receivers in the literature, while relying on a nonlinear, DFE-like sequential structure that avoids matrix inversions and exhibits lower computational complexity than existing sequential equalizers. In addition, the peak-to-average power ratio (PAPR) is incorporated into the evaluation framework for FTN signaling, enabling the identification of operating regimes where the proposed receiver offers a particularly attractive trade-off among performance, computational complexity, and PAPR. Finally, we address the problem of coarse synchronization for FTN signaling by proposing methods based on the generalized likelihood ratio test (GLRT) and comparing their performance against that of Nyquist-compliant transmissions. This study contributes to a better understanding of the fundamental limitations of FTN systems by showing that performance degradation primarily stems from the reduced duration of the time-compressed signal rather than from the FTN shaping filter itself and opens new perspectives for their practical implementation.
Surface treatment & functionalization via femtosecond laser irradiation in GHz-burst mode
by Théo GUILBERTEAU (Centre Lasers Intenses et Applications)
The defense will take place at 14h00 - Amphitheatre D A29, 351 Cr de la Libération, 33400 Talence
in front of the jury composed of
- Inka MANEK-HÖNNINGER - Professeure des universités - Université de Bordeaux - Directeur de these
- François COURVOISIER - Directeur de recherche - FEMTO-ST Institute, CNRS, Universite de Franche-Comte - Examinateur
- Emmanuel D'HUMIÈRES - Professeur des universités - Université de Bordeaux - Examinateur
- F. Ömer ILDAY - Full professor - Ruhr Universität Bochum - Rapporteur
- Jean-Phillipe COLOMBIER - Professeur des universités - UJM Saint-Etienne, CNRS, Institute of Optics Graduate School, Laboratoire Hubert Curien - Rapporteur
Femtosecond lasers are widely recognized for their ability to perform high‑precision surface treatment and functionalization thanks to strongly localized energy deposition and reduced heat affected zones. Despite these advantages, their industrial adoption remains limited due to high system costs and insufficient throughput of the associated processes. In conventional low‑repetition‑rate regimes, the available average power is not always fully exploited; the high accuracy and machining quality of femtosecond processing is obtained through an increase of processing times. In this context, this thesis investigates strategies to improve the efficiency and controllability of femtosecond laser surface treatment and functionalization through spatial and temporal beam shaping. Emphasis is placed on the GHz‑burst regime, in which a single laser pulse is divided into a train of lower‑energy sub‑pulses separated by very short time delays, promoting cooperative pulse‑to‑pulse effects and more efficient energy deposition. The work deals with both metallic and dielectric materials. Surface functionalization of AISI 316L stainless steel is investigated through GHz‑burst laser polishing, with a detailed analysis of the influence of burst configuration, spatial beam shaping (Gaussian and vortex beams), spatial overlap, and initial surface condition on process efficiency and final surface quality. In parallel, structuring of transparent dielectric materials is explored using Bessel beams operated in single‑pulse, MHz‑burst, and GHz‑burst regimes, enabling the generation of high‑aspect‑ratio modifications. To gain deeper insight into the laser–matter interaction mechanisms specific to the GHz‑burst regime, time‑resolved diagnostics combining pump–probe shadowgraphy and Mach–Zehnder interferometry are employed. These measurements provide access to plasma dynamics and in‑volume energy deposition, allowing direct comparison between MHz‑ and GHz‑burst regimes. Overall, the results demonstrate the potential of GHz‑burst irradiation combined with tailored beam shaping to reconcile high‑precision surface functionalization with improved throughput in ultrafast laser material processing.
ED Sociétés, Politique, Santé Publique
The role of optimism in cancer prevention and in potentially traumatic post-treatment repercussions
by Louis HEBRARD (Bordeaux Population Health Research Center)
The defense will take place at 14h00 - Amphi Pitres Université de Bordeaux, 3 Ter Place de la Victoire, 33000 Bordeaux
in front of the jury composed of
- Nicole RASCLE - Professeure émérite - Université de Bordeaux - Directeur de these
- Nicole CANTISANO - Maîtresse de conférences - Centre d'Etudes et de Recherches en Psychopathologie et Psychologie de la Santé (CERPPS) - Rapporteur
- Cécile FLAHAULT - Maîtresse de conférences - Université Paris Cité – Institut de Psychologie - Rapporteur
- Jérôme FOUCAUD - Docteur - Université Paris 13 - Examinateur
- Bruno QUINTARD - Professeur des universités - Université de Bordeaux - Examinateur
- Michèle KOLECK - Professeure - Université de Bordeaux - Examinateur
This doctoral research examines the role of optimism in the context of cancer across two complementary perspectives: the prevention of cancer-related risk behaviors and psychosocial adjustment after cancer treatment. It includes three studies. The first focuses on the assessment of optimism through the French validation of a measure of dispositional optimism for children and adolescents, and the replication of an experimental paradigm evaluating optimism bias. The second study explores how optimism influences engagement in behaviors associated with colorectal cancer risk and attitudes toward screening. The final study investigates the contribution of optimism to psychosocial adjustment following cancer treatment, with particular attention to trauma-related symptoms.